In 2018, the Canadian Public Health Association (CPHA) released a position statement entitled A Public Health Approach to Nicotine-containing Vaping Devices, which provided recommendations (Appendix 2) concerning their regulation. Since the release of that statement, nicotine-containing e-cigarettes were legalized (2019) and regulated, and a significant body of information has developed concerning the use of vaping products. That information must be considered as steps are proposed to regulate further the sale of vaping devices. The challenge is to recognize the differences and similarities between tobacco and vaping products and understand their differing health and health equity implications. It is also necessary to recognize the success achieved to date in reducing smoking prevalence, and the challenges associated with making further progress. Understanding these challenges will lead to options that address the current needs of those who are more susceptible to tobacco consumption and nicotine addiction.