This document is intended to supplement the BCCSU Guideline for the Clinical Management of Opioid Use Disorder (“Guideline”) with an overview of care principles and treatment options specifically pertaining to pregnant individuals. This guideline recognizes persisting misconceptions about pregnant people who use substances as a primary barrier to accessing treatment for opioid use disorder during pregnancy, and emphasizes the need for a non-judgmental, trauma-informed and culturally safe approach to care that accommodates patients’ individual choices and circumstances. Within this framework, the present document recommends a holistic and integrated care plan with appropriate use of the full range of available long-term treatment options and harm reduction services.