'Discussing sexual health, substance use and STBBIs: A guide for service providers' aims to reduce stigma by offering strategies that facilitate safer and more respectful discussions about sexual health, substance use and STBBIs between service providers and clients. The guide also offers ways to improve prevention, diagnosis and treatment of STBBIs. The discussion guide is based on the Centers for Disease Control and Prevention document A Guide to taking a sexual history and has been updated following a literature review and pilot testing with practitioners and people with lived experience of STBBIs from across Canada. It can be used by nurses, physicians, health educators, social workers and others working in sexual health, harm reduction or STBBI-specific services, as well as those working in general health and social services.